从这篇开始我就正式接触科研了，对于每一篇文章都尽量做一个良好的学习。会针对分析、概括、思考、代码等等方便对文章进行学习。主要起到一个确保自己当下学懂和未来能够用到的作用。
不苛求形式，即使博客本身形式性就很强。我会尽量做到更新，或以博客记录，或者把自己的电子手写稿粘贴上来。如果对我的内容有疑问，欢迎批评与指正。

# 单词对应

由于对这方面尚不太熟悉，会在自己阅读时把自己不熟悉的单词进行标注。

# 原文摘录

what exactly is a cell type? "A cell type is a group of cells that are similar to each other and distinct fromother groups of cells"

Some researchers reject the view that a cell is a simple summation of gene expression, as atlases based on RNA sequencing imply.Other argue that a cell's progression through various states over time must also be considered.

There's a general consensus that it is extremely complicated

...some tools for cell-typing....But none of those tools says mach about what astrocytes do, which is to support neurons and synapses.

cell function might be the best way to define a cell type.And part of a cell's function is its response to its environment.

Unfortunately,cell responses and functions are not obvious for many cell types, and might be transient features.

By combining those approaches, "we've really redefined what cell types are"

Have map, will travel

there are two camps: One camp looks at cells, and the other camp looks at genes

(cell-focused camp) He says that single-cell RNA sequencing creates a gene-centric view that distracts scientists from other questions.

(genes-focused camp) Genes are the fundamental unit of life, and cells are manifestations of those genes."You tell me which genes are on, I'll tell you what cell type"
(插句嘴，我目前更倾向于第一种，第二种应当在研究基因，而非研究细胞)

Another rubric for defining cell type is to lookk at the physical state of the genome in the neclus - how the genome forms loops and coils...

theory:cell types are controlled by large complexes of transcription fators and other molecules celled the 'core regulatory complex' or CoRC.

CoRC is "kind of like the unicorn that you're searching for, for what a cell type is"

A cell's pasr and future are just as crucial. ... Even cells with seemingly stable identities might have the potential to turn into different types.

A parts list in an atlas under-prioritizes the concept of time and the notion of continuity.

There are rare instances when types that seem identical can arise through different trajectories.

there's a question of is cell identity a continuous property, is it a discrete property?

...have come to see cells less as members of a particular type, and more as collections of identities, based on the modules or pathways that a given cell is running at a given time .

# 概括总结

先是提出问题，为什么要去区分细胞的类型，引出我们该如何去定义它。

# 科技改变了分类学

最开始从显微镜的角度从形态上区分细胞，到从细胞分泌物去区分细胞，到如今从基因的角度区分细胞。总结出来我们要结合多种方法才能区分细胞

# atlas 可以引领我们去探索

强调了 atlas 的重要性，指出至今仍有很多细胞种类被挖掘出来，而通过类比物种之间的细胞数据可以发现物种之间的相似性，从而更好的去研究。

# 更深入的定义

两个阵营：细胞派和基因派，看得出来作者更倾向于基因派
分别是从细胞的角度和基因的角度去定义细胞类型。

# 时间与状态

强调时间对于定义细胞的重要性和困难程度。

# 同意与不同意

定义是模糊且艰难的， 但这并不意味着它没有用。